Description

SPRAVATO, the only FDA-approved nasal spray for
adult patients with two forms of challenging-to-treat
major depressive disorder (MDD):

Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, is the S(+) enantiomer of ketamine. It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression. Esketamine is the active enantiomer of ketamine in terms of NMDA receptor antagonism and is more potent than racemic ketamine.

It is specifically used as a therapy for treatment-resistant depression (TRD) and for major depressive disorder (MDD) with co-occurring suicidal ideation or behavior. Its efficacy for depression is modest and similar to that of other antidepressants. Esketamine is not used by infusion into a vein for anesthesia as it is only FDA approved for depression in the form of an intranasal spray (the parent compound Ketamine is most often administered intravenously) and under direct medical supervision as a nasal spray.

• Adults with MDD who’ve had an inadequate response to two or more oral antidepressants, known as treatment-resistant depression (TRD)
• Depressive symptoms in adults with MDD with suicidal thoughts or actions (MDSI)

Buy Spravato nasal spray, without preservatives, suitable for children aged 6 and over.

How will I take SPRAVATO^®?

• You will take SPRAVATO  nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting. Your healthcare provider will show you how to use the SPRAVATO  nasal spray device.
• Your healthcare provider will tell you how much SPRAVATO  you will take and when you will take it.
• Follow your SPRAVATO  treatment schedule exactly as your healthcare provider tells you to.
• During and after each use of the SPRAVATO nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.
• You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO
• If you miss a SPRAVATO  treatment, your healthcare provider may change your dose and treatment schedule.
• Some people taking SPRAVATO  get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO  and not drink liquids at least 30 minutes before taking SPRAVATO
• If you take a nasal corticosteroid or nasal decongestant medicine take these medicines at least 1 hour before taking SPRAVATO.

What should I avoid while taking SPRAVATO^®?

Do not drive, operate machinery, or do anything where you need to be completely alert after taking SPRAVATO  Do not take part in these activities until the next day following a restful sleep. See “What is the most important information I should know about SPRAVATO ?”

What are the possible side effects of SPRAVATO ?

SPRAVATO  may cause serious side effects including:

• See “What is the most important information I should know about SPRAVATO^®?”
• Increased blood pressure. SPRAVATO  can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO  and for at least 2 hours after you take SPRAVATO . Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO
• Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.
• Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

Allergy information
If you are allergic to xylometazoline hydrochloride, dexpanthenol, potassium dihydrogen phosphate or disodium hydrogen phosphate, then nasal spray should not be used.

Ingredients
What nasal spray 1 mg/ml + 50 mg/ml contains, Buy Spravato nasal spray

The active ingredients are:
xylometazoline hydrochloride/dexpanthenol. One spray (equivalent to 0.1 ml solution) contains 0.1 mg xylometazoline hydrochloride and 5.0 mg dexpanthenol. 1 ml solution contains: 1 mg xylometazoline hydrochloride and 50 mg dexpanthenol.

The other ingredients are:
potassium dihydrogen phosphate, disodium hydrogen phosphate, water for injections.